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This research work focuses on spatio-temporal pattern of motorcycle accidents in Anambra state, Nigeria. The study used mostly secondary data, accident records which were obtained from Federal Road Safety Commission Awka, Anambra state (RS 5.30). The data on motorcycle accidents were obtained for a period of ten (10) years (2007-2016). Analysis of variance (ANOVA) technique was employed in the examination of the statistical significance of the variation among the local government areas of the state. The result indicates that there is a significant variation in the number of motorcycle accidents among the local government areas of the state (F29, 189 = 2.609; p<0.05). Again analysis of variance was employed in the examination of the statistical significance of the variation of motorcycle accidents over time (2007-2016) in Anambra state. The result indicates that there is a significant difference in the number of motorcycle accidents from 2007-2016 (F9, 200= 13.210; p<0.05). Multiple regression analysis was employed in the examination of some of the characteristics of the local government areas of the state. It was observed that, there is a joint prediction of motorcycle accidents by a combination of some of the characteristics of the LGA of the state (p<0.05), the result implies that other characteristics of the Local Government areas of the state played little influence on the number of motorcycle accidents that occurred in 2011. The need for re-orientation of the land use pattern in the study area, better road network characteristics, Government should set up more police patrols for the highways in order to enforce road traffic regulation including speed limits and the need to establish Federal Road Safety Corps archive where accident records will be kept, collated and processed are desirable.